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Selective elimination of low‐molecular‐weight ions in MALDI‐TOF mass spectrometry using a bipolar pulsed electrostatic particle guide
Author(s) -
Just Craig L.,
Hanson Curtiss D.
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290070620
Subject(s) - chemistry , microchannel plate detector , mass spectrometry , ionization , ion , detector , microchannel , analytical chemistry (journal) , matrix assisted laser desorption/ionization , desorption , atomic physics , chromatography , optics , nanotechnology , adsorption , physics , materials science , organic chemistry
This study addresses a problem inherent in the use of microchannel plates as detectors for matrix‐assisted laser desorption/ionization. We have developed a unique new method of ion transport using fast bipolar pulsing of an electrostatic particle guide to provide ion deflection and enhanced ion transmission. This mode of operation effectively eliminates the intense low‐mass component of the spectrum which normally saturates microchannel ‐plate detectors, while at the same time transporting the higher‐mass component with high efficiency. Enhancement of the resulting signal‐to‐noise ratio has been achieved.