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Gas chromatography/mass spectrometric analysis of urinary nucleosides in cancer patients; potential of modified nucleosides as tumour markers
Author(s) -
Langridge James I.,
McClure Tom D.,
EiShakawi Salah,
Fielding Andrew,
Schram Karl H.,
Newton Russell P.
Publication year - 1993
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290070605
Subject(s) - chemistry , urine , chromatography , nucleoside , mass spectrometry , urinary system , gas chromatography , capillary gas chromatography , adenosine , gas chromatography–mass spectrometry , cancer , biochemistry , medicine
Analysis of urine from cancer patients by capillary gas chromatography/mass spectrometry positively identified 14 urinary nucleosides including several modified nucleosides. Levels of the modified nucleosides 1‐methyl‐adenosine, 2‐methylguanosine, N 2 ,N 2 ‐dimethylguanosine and 1‐methylinosine as well as the total nucleoside level were elevated in the urine when a malignant tumour was present; the levels of N 2 ,N 2 ‐dimethylguanosine were found to correlate with the stage of the cancer.