Gas chromatography/mass spectrometric analysis of urinary nucleosides in cancer patients; potential of modified nucleosides as tumour markers | Zendy

Langridge James I. | Zendy; McClure Tom D. | Zendy; EiShakawi Salah | Zendy; Fielding Andrew | Zendy; Schram Karl H. | Zendy; Newton Russell P. | Zendy

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Gas chromatography/mass spectrometric analysis of urinary nucleosides in cancer patients; potential of modified nucleosides as tumour markers

Author(s) -

Langridge James I.,

McClure Tom D.,

EiShakawi Salah,

Fielding Andrew,

Schram Karl H.,

Newton Russell P.

Publication year - 1993

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.1290070605

Subject(s) - chemistry , urine , chromatography , nucleoside , mass spectrometry , urinary system , gas chromatography , capillary gas chromatography , adenosine , gas chromatography–mass spectrometry , cancer , biochemistry , medicine

Analysis of urine from cancer patients by capillary gas chromatography/mass spectrometry positively identified 14 urinary nucleosides including several modified nucleosides. Levels of the modified nucleosides 1‐methyl‐adenosine, 2‐methylguanosine, N 2 ,N 2 ‐dimethylguanosine and 1‐methylinosine as well as the total nucleoside level were elevated in the urine when a malignant tumour was present; the levels of N 2 ,N 2 ‐dimethylguanosine were found to correlate with the stage of the cancer.

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