On‐line isotachophoretic analyte focusing for improvement of detection limits in capillary electrophoresis/electrospray mass spectrometry | Zendy

Tinke A. P. | Zendy; Reinhoud N. J. | Zendy; Niessen W. M. A. | Zendy; Tjaden U. R. | Zendy; van der Greef J. | Zendy

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On‐line isotachophoretic analyte focusing for improvement of detection limits in capillary electrophoresis/electrospray mass spectrometry

Author(s) -

Tinke A. P.,

Reinhoud N. J.,

Niessen W. M. A.,

Tjaden U. R.,

van der Greef J.

Publication year - 1992

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.1290060905

Subject(s) - chemistry , capillary electrophoresis , analyte , chromatography , capillary electrophoresis–mass spectrometry , electrospray , mass spectrometry , electrospray mass spectrometry , isotachophoresis , analytical chemistry (journal) , electrophoresis , detection limit , capillary action , electrospray ionization , electrode , electrolyte , materials science , composite material

Detectability enhancement in capillary electrophoresis/mass spectrometry (CE/MS) has been realized using on‐line isotachophoretic (ITP) analyte focusing. This is demonstrated for the analysis of a mixture of anthracyclines, showing on at least 200‐fold improvement detectable concentration for ITP/CE/MS compared to CE/MS using an electrospray (ESP) interface.

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