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On‐line isotachophoretic analyte focusing for improvement of detection limits in capillary electrophoresis/electrospray mass spectrometry
Author(s) -
Tinke A. P.,
Reinhoud N. J.,
Niessen W. M. A.,
Tjaden U. R.,
van der Greef J.
Publication year - 1992
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290060905
Subject(s) - chemistry , capillary electrophoresis , analyte , chromatography , capillary electrophoresis–mass spectrometry , electrospray , mass spectrometry , electrospray mass spectrometry , isotachophoresis , analytical chemistry (journal) , electrophoresis , detection limit , capillary action , electrospray ionization , electrode , electrolyte , materials science , composite material
Detectability enhancement in capillary electrophoresis/mass spectrometry (CE/MS) has been realized using on‐line isotachophoretic (ITP) analyte focusing. This is demonstrated for the analysis of a mixture of anthracyclines, showing on at least 200‐fold improvement detectable concentration for ITP/CE/MS compared to CE/MS using an electrospray (ESP) interface.