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Thermally induced dissociation of ions from electrospray mass spectrometry
Author(s) -
Rockwood Alan L.,
Busman Mark,
Udseth Harold R.,
Smith Richard D.
Publication year - 1991
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290051203
Subject(s) - chemistry , dissociation (chemistry) , fragmentation (computing) , mass spectrometry , electrospray , ion , electrospray ionization , protonation , molecule , analytical chemistry (journal) , ionization , collision induced dissociation , capillary action , tandem mass spectrometry , atmospheric pressure , ambient ionization , ion source , chemical ionization , chromatography , organic chemistry , materials science , oceanography , computer science , composite material , geology , operating system
Abstract The thermally induced dissociation (TID) of inos at near atmospheric pressure, followed by their mass spectraometric analysis, is demonstrated. The TID occurs in a heated metal capillary interface, and should be broadly applicable to any system capable of producing ions at high pressure. The heated capillary provides a reaction vessel , potentially very useful for kinetic and mechanistic studies of ions. The technique has been applied to the fragmentation of large multiply charged ions from an electrospray ionization source. Preliminary results show that stability for multiply protonated petide or protein molecules in inversely related to its charge.