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Suitability of fast‐ion bombardment mass spectrometry for the investigation of 1,4‐dihydropyridine derivatives
Author(s) -
Hamdan M.,
Scandola M.,
Franchi D.,
Tarzia G.,
Gaviraghi G.
Publication year - 1991
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290051102
Subject(s) - chemistry , ion , mass spectrometry , mass spectrum , fragmentation (computing) , ionization , electron ionization , analytical chemistry (journal) , chemical ionization , ion source , chromatography , organic chemistry , computer science , operating system
Positive/negative fast‐ion bombardment (FIB + /FIB − , negative‐ion chemical ionization (CI − ) and positive‐ion electron ionization (EI + )mass spectrometry are used to investigate a number of 1,4‐dihydropyridine derivatives. The FIB + mass spectra presented, acquired at fixed C s + ion‐gun voltage as well as at different voltages ranging from 1–16 kV, display a close resemblance to their EI + mass spectral counterparts. Comparison of the FIB − data with data acquired in ammonia CI − demonstrates that for the type of compound investigated in this work, the latter ionization technique yields a superior molecular anion signal and negligible fragmentation. Some of the FIB + mass spectra presented display a number of unmistakeable qualitative differences which are tentatively attributed to the isomeric stereo‐chemistry of the compounds investigated.