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High mass‐resolution using a quadrupole ion‐trap mass spectrometer
Author(s) -
Williams Jon D.,
Cox Kathleen A.,
Cooks R. Graham,
Kaiser Raymond E.,
Schwartz Jae C.,
Gaskell S. J.
Publication year - 1991
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290050706
Subject(s) - chemistry , quadrupole ion trap , hybrid mass spectrometer , mass spectrometry , quadrupole mass analyzer , ion trap , ion , triple quadrupole mass spectrometer , analytical chemistry (journal) , resolution (logic) , horizontal scan rate , quadrupole , atomic physics , selected reaction monitoring , tandem mass spectrometry , physics , chromatography , cyclic voltammetry , organic chemistry , electrode , artificial intelligence , computer science , electrochemistry
Modifications have been made to the quadrupole ion‐trap mass spectrometer (ITMS) to improve the resolution. An offset‐digital‐to‐analog converter/attenuator network is used to slow down the scan rate in the mass‐selective instability mode of operation with reasonance ejection. Attenuations of the scan rate by 200 to 700 times increase the resolution from 500 (with no attenuation) to 40 000 and 100 000 (full width at half maximum), respectively, for the [M + H] + peak of substance p ( m / z 1348). These improved resolutions are achieved in experiments which use resonance ejection to extend the mass‐to‐charge range.