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Direct evidence for degradation of esperamicin A 1 with thiol confirmed by fast‐atom bombardment mass spectrometry
Author(s) -
Takayama Mitsuo,
Nomura Taro,
Konishi Masataka
Publication year - 1991
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290050510
Subject(s) - chemistry , fast atom bombardment , thiol , mass spectrometry , degradation (telecommunications) , mass spectrum , matrix isolation , matrix (chemical analysis) , analytical chemistry (journal) , chromatography , molecule , organic chemistry , telecommunications , computer science
A degradation of esperamicin A 1 , which is a potent antitumor antibiotic having DNA‐cleaving activity, was studied by fast‐atom bombardment (FAB) mass spectrometry. It was proved that the degradation easily occurs via the thiol group(s) in the matrix solution and not by a FAB‐induced reaction. It was concluded that from the FAB mass spectra of all non‐volatile compounds, the molecular weight should be determined by using at least two chemically different matrices.