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Unimolecular decomposition of M + ˙ and [M + H] + species of some fluorosubstituted acyclic nucleoside analogs
Author(s) -
Favretto Donata,
Traldi Pietro,
Bravo Pierfrancesco,
Viani Fiorenza
Publication year - 1991
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290050206
Subject(s) - chemistry , fragmentation (computing) , electron ionization , mass spectrometry , decomposition , kinetic energy , computational chemistry , ionization , fast atom bombardment , nucleoside , stereochemistry , ionization energy , analytical chemistry (journal) , medicinal chemistry , ion , organic chemistry , chromatography , physics , quantum mechanics , computer science , operating system
Electron ionization and fast‐atom bombardment mass spectrometry are shown to provide a valid analytical tool for the structural characterization of the title compounds. In fact, diagnostic fragmentation pathways were observed depending on the presence of different substituents (benzyloxy, p ‐tolylthio, p ‐tolylsulphinyl) as swell as of different bases. Regioisomeric compounds could be differentiated by kinetic energy release measurements.