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Performance of a liquid‐junction interface for capillary electrophoresis mass spectrometry using continuous‐flow fast‐atom bombardment
Author(s) -
Reinhoud N. J.,
Niessen W. M. A.,
Tjaden U. R.,
Gramberg L. G.,
Verheij E. R.,
van der Greef J.
Publication year - 1989
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1290031009
Subject(s) - chemistry , capillary electrophoresis , fast atom bombardment , mass spectrometry , analytical chemistry (journal) , chromatography , capillary electrophoresis–mass spectrometry , capillary action , resolution (logic) , bioanalysis , electrophoresis , coupling (piping) , electrospray ionization , materials science , artificial intelligence , computer science , composite material , mechanical engineering , engineering
The on‐line coupling of capillary electrophoresis and mass spectrometry using a continuous‐flow fast‐atom bombardment system in combination with a liquid‐junction interface is described. The influence of the liquid‐junction coupling on the efficiency and the resolution is investigated. Qualitative analysis of small peptides and quantitative analysis of dextromethorphan is demonstrated with detection limits in the low ng/mL range, indicating the feasibility of the method in bioanalysis.