Negative ion electrospray mass spectrometry of aminomethylphosphonic acid and glyphosate: elucidation of fragmentation mechanisms by multistage mass spectrometry incorporating in‐source deuterium labelling | Zendy

Goodwin Lee | Zendy; Startin James R. | Zendy; Goodall David M. | Zendy; Keely Brendan J. | Zendy

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Negative ion electrospray mass spectrometry of aminomethylphosphonic acid and glyphosate: elucidation of fragmentation mechanisms by multistage mass spectrometry incorporating in‐source deuterium labelling

Author(s) -

Goodwin Lee,

Startin James R.,

Goodall David M.,

Keely Brendan J.

Publication year - 2003

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.1264

Subject(s) - chemistry , aminomethylphosphonic acid , mass spectrometry , electrospray , fragmentation (computing) , chromatography , deuterium , ion trap , selected reaction monitoring , analyte , top down proteomics , phosphonate , electrospray ionization , tandem mass spectrometry , metabolite , organic chemistry , biochemistry , physics , quantum mechanics , computer science , operating system

Glyphosate and its main metabolite, aminomethylphosphonic acid, introduced by direct infusion in 2 H 2 O, appear in negative ion electrospray mass spectrometry (ES‐MS) as triply deuteriated [MH] − ions. Sites of deuterium residence and loss were established using the multistage (MS n ) capabilites of an ion trap mass spectrometer to assist in the determination of fragmentation mechanisms. The study reveals specific mechanisms, common to each analyte, such as those involving a five‐membered transition state between the amine and phosphonate group, as well as analyte specific transitions. Copyright © 2003 John Wiley & Sons, Ltd.

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