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Characterization of ammonium chloride derivatives by salt clustering in electrospray mass spectrometry
Author(s) -
Charles Laurence,
Chiron Julien,
Galy JeanPierre
Publication year - 2003
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1216
Subject(s) - chemistry , counterion , mass spectrum , salt (chemistry) , mass spectrometry , cluster (spacecraft) , electrospray , electrospray ionization , chloride , ammonium chloride , hydrochloride , monomer , ionic bonding , electrospray mass spectrometry , ammonium , inorganic chemistry , ion , analytical chemistry (journal) , chromatography , organic chemistry , computer science , programming language , polymer
Clustering of ammonium chloride salts was studied using an electrospray source to characterize the form, mono‐ vs. dihydrochloride, of organic compounds by mass spectrometry. This new way of taking advantage of cluster formation is applied to aminomethylacridines as their storage requires the synthesis of such derivatives. Both positive and negative cluster mass spectra were obtained and allowed the determination of the nature of the hydrochloride forms as the salt mass is straightforwardly derived from the mass of the cluster monomer, calculated from singly and multiply charged ion distributions. The identity of the counterion is confirmed from the mass of the ionic moieties in the clusters. Copyright © 2003 John Wiley & Sons, Ltd.