Premium
Automated multiple‐layer spotting for matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry of synthetic polymers utilizing ink‐jet printing technology
Author(s) -
Meier Michael A. R.,
de Gans BerendJan,
van den Berg Antje M. J.,
Schubert Ulrich S.
Publication year - 2003
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1195
Subject(s) - chemistry , mass spectrometry , polymer , analyte , sample preparation , ethylene glycol , desorption , matrix (chemical analysis) , time of flight mass spectrometry , matrix assisted laser desorption/ionization , chromatography , analytical chemistry (journal) , ionization , organic chemistry , ion , adsorption
Recently, a new multiple‐layer matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) sample spotting technique for poly(ethylene glycol), offering improved analysis possibilities, was described. In this contribution the application of ink‐jet printing to automated, multiple‐layer MALDI‐TOFMS sample preparation of synthetic polymers is presented, allowing accurate deposition of matrix, additive and analyte solutions. The new sample preparation technique was evaluated for poly(ethylene glycol) as well as poly(methyl methacrylate) standards, and optimized settings for both synthetic polymers have been obtained. Copyright © 2003 John Wiley & Sons, Ltd.