Analysis of urinary nucleosides. III. Identification of 5′‐deoxycytidine in urine of a patient with head and neck cancer | Zendy

Dudley Edward | Zendy; Lemiere Filip | Zendy; Van Dongen Walter | Zendy; Langridge James I. | Zendy; ElSharkawi Salah | Zendy; Games David E. | Zendy; Esmans Eddy L. | Zendy; Newton Russell P. | Zendy

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Analysis of urinary nucleosides. III. Identification of 5′‐deoxycytidine in urine of a patient with head and neck cancer

Author(s) -

Dudley Edward,

Lemiere Filip,

Van Dongen Walter,

Langridge James I.,

ElSharkawi Salah,

Games David E.,

Esmans Eddy L.,

Newton Russell P.

Publication year - 2003

Publication title -

rapid communications in mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.528

H-Index - 136

eISSN - 1097-0231

pISSN - 0951-4198

DOI - 10.1002/rcm.1034

Subject(s) - chemistry , urine , chromatography , mass spectrometry , deoxycytidine , nucleoside , high performance liquid chromatography , protonation , urinary system , cancer , stereochemistry , medicine , biochemistry , ion , organic chemistry , gemcitabine

Modified nucleosides in the urine have been postulated to be diagnostic indices of disease, particularly of cancer. The urine of a patient with terminal head and neck cancer has been found to contain a modified nucleoside with a protonated molecule of m/z 228. By means of high‐performance liquid chromatography/ion trap mass spectrometry (HPLC/ITMS) and capillary liquid chromatography/triple quadruple mass spectrometry (CapLC/TQMS) we have identified the compound as 5′‐deoxycytidine. This is the first report of 5′‐deoxycytidine in man: in addition to the elucidation of its structure, its possible origins and the potential significance of its occurrence are discussed. Copyright © 2003 John Wiley & Sons, Ltd.

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