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Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes
Author(s) -
Cui Meng,
Mester Zoltán
Publication year - 2003
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1030
Subject(s) - chemistry , electrospray ionization , chromatography , mass spectrometry , aqueous solution , hydrolysis , electrospray , liquid chromatography–mass spectrometry , extractive electrospray ionization , dimer , ionization , sample preparation in mass spectrometry , organic chemistry , ion
Electrospray ionization mass spectrometry (ESI‐MS) coupled to liquid chromatography (LC) has been applied to investigate cisplatin and its hydrated complexes. Three hydrolysis products were identified following incubation of cisplatin in aqueous solution: monohydrated species, dihydrated species and the hydroxo‐bridged dimer, each of which exhibited characteristic mass spectrometric behavior. The technique was employed to investigate the time‐ and pH‐dependent hydrolysis of cisplatin in aqueous solution. The results have demonstrated that LC/ESI‐MS is a powerful technique for the analysis of Pt(II) complexes and for monitoring their hydrolysis reactions. Copyright © 2003 Crown in the right of Canada. Published by John Wiley & Sons, Ltd.