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Product ion scanning using a Q‐q‐Q linear ion trap (Q TRAP TM ) mass spectrometer
Author(s) -
Hager James W.,
Yves Le Blanc J. C.
Publication year - 2003
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1020
Subject(s) - quadrupole ion trap , chemistry , ion trap , mass spectrometry , triple quadrupole mass spectrometer , ion , hybrid mass spectrometer , analytical chemistry (journal) , quadrupole mass analyzer , fragmentation (computing) , quadrupole , selected reaction monitoring , spectrometer , ion source , atomic physics , tandem mass spectrometry , physics , optics , chromatography , organic chemistry , computer science , operating system
The use of a Q‐q‐Q linear ion trap instrument to obtain product ion spectra is described. The instrument is based on the ion path of a triple quadrupole mass spectrometer with Q3 operable as either a conventional RF/DC quadrupole mass filter or a linear ion trap mass spectrometer with axial ion ejection. This unique ion optical arrangement allows de‐coupling of precursor ion isolation and fragmentation from the ion trap itself. The result is a high sensitivity tandem mass spectrometer with triple quadrupole fragmentation patterns and no inherent low mass cut‐off. The use of the entrance RF‐only section of the instrument as accumulation ion trap while the linear ion trap mass spectrometer is scanning enhances duty cycles and results in increased sensitivities by as much as a factor of 20. The instrument is also capable of all of the triple quadrupole scans including multiple‐reaction monitoring (MRM) as well as precursor and constant neutral loss scanning. The high product ion scanning sensitivity allows the recording of useful product ion spectra near the MRM limit of quantitation. Copyright © 2003 John Wiley & Sons, Ltd.