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Covariance mapping in matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
Author(s) -
Feldman Andrew B.,
Antoine Miquel,
Lin Jeffrey S.,
Demirev Plamen A.
Publication year - 2003
Publication title -
rapid communications in mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.528
H-Index - 136
eISSN - 1097-0231
pISSN - 0951-4198
DOI - 10.1002/rcm.1013
Subject(s) - chemistry , mass spectrometry , ionization , desorption , laser , analytical chemistry (journal) , matrix assisted laser desorption/ionization , matrix assisted laser desorption electrospray ionization , time of flight mass spectrometry , matrix (chemical analysis) , ion , sample (material) , surface enhanced laser desorption/ionization , chromatography , electron ionization , optics , physics , organic chemistry , adsorption
A novel method for acquisition and numerical analysis of matrix‐assisted laser desorption/ionization (MALDI) time‐of‐flight mass spectral data is described. The digitized ion current transient from each consecutive laser shot is first acquired and stored independently. Subsequently, statistical correlation parameters between all stored transients are computed. We illustrate the uses of this event‐by‐event analysis method for studies of sample surface heterogeneity as well as for elucidating the mechanisms of ion formation in MALDI. Other potential applications of the method are also outlined. Copyright © 2003 John Wiley & Sons, Ltd.