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Structure–activity relationships of ion transport compounds
Author(s) -
Khutorsky V. E.
Publication year - 1992
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560440718
Subject(s) - chemistry , siderophore , ion , solvent , membrane , computational chemistry , monte carlo method , chemical physics , ion transporter , permeability (electromagnetism) , biophysics , organic chemistry , biochemistry , statistics , mathematics , biology , gene
Abstract Transport of ions through membrane by different chemical compounds is analyzed on the basis of conformational analysis and Monte Carlo calculations performed in the author's works. Ionophores, siderophores, and channels are considered. The complex formation of ionophores is accompanied by the formation of intermediate exclusive and solvent‐shared states. The siderophores' hydration determines their activity. The changes in the channels' permeability are related to the changes in the pore diameter. © 1992 John Wiley & Sons, Inc.