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Inter‐ and intramolecular motions in proteins
Author(s) -
Parak Fritz
Publication year - 1992
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560420523
Subject(s) - intramolecular force , myoglobin , dynamics (music) , mössbauer spectroscopy , chemistry , molecular dynamics , protein dynamics , chemical physics , amplitude , crystallography , scattering , molecular physics , physics , computational chemistry , optics , stereochemistry , organic chemistry , acoustics
The use of 57 Fe Mössbauer radiation allows the study of protein crystal dynamics by a time‐resolved analysis of X‐ray scattering. In myoglobin cystals, the main source of the root mean squared amplitude of motions comes from intramolecular protein dynamics. Segments of the size of an α‐helix move collectively. Long‐range correlated motions give only a minor contribution. Comparison with Mössbauer absorption spectroscopy shows that protein‐specific dynamics is frozen out below 200 K and the lattice dynamics is mainly responsible for the low‐temperature behavior.