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On the possible mode of regulation of DNA transcription by steroid hormones: Glucocorticoids
Author(s) -
Kothekar V.,
Kotwal A.,
Chandrashekhar B.
Publication year - 1988
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560340715
Subject(s) - glucocorticoid receptor , steroid , hormone , dexamethasone , glucocorticoid , steroid hormone , transcription factor , transcription (linguistics) , energy minimization , hormone response element , chemistry , dna , sequence (biology) , endocrinology , medicine , biology , gene , genetics , biochemistry , computational chemistry , estrogen receptor , linguistics , philosophy , cancer , breast cancer
We present models for the interaction of glucocorticoids: dexamethasone (DEX), dexamethasone‐21‐mesylate (DEXM) and deacylcortivazol (DAC) with the hexanucleotide sequence d(TGTTCT) 2 (CORE sequence) found in the long terminal repeat of MMTV. These models are obtained by computer‐aided geometry simulation with energy minimization technique, making use of the empirical potential energy functions. We have considered both intercalative and nonintercalative binding. Differences in the glucocorticoid activity of these steroids are explained on the basis of stereochemical and energetic differences. A model is proposed for interaction of the steroid–receptor complex with the hormone‐responsive element (HRE).