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Some recent developments concerning the mechanisms of tumor promotion
Author(s) -
Thomson Colin
Publication year - 2009
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560300830
Subject(s) - tumor promotion , promotion (chess) , phorbol ester , relevance (law) , cancer research , protein kinase c , chemistry , computational biology , gene , political science , kinase , bioinformatics , biology , biochemistry , carcinogenesis , politics , law
Recent developments in tumor promotion are reviewed, particularly the biochemical effects of phorbol esters and new tumor promoters such as the teleocidins. The role of active oxygen species, and the nature and properties of the phorboid receptor, protein kinase C, are discussed. Finally, the relevance of gene expression to promotion, and of promotion to human cancer are explored.