Premium
Electrostatic effect on catalytic rate enhancement in serine proteinases
Author(s) -
NáraySzabó G.
Publication year - 1982
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560220309
Subject(s) - serine , subtilisin , chemistry , catalysis , amino acid , statement (logic) , side chain , biochemistry , enzyme , organic chemistry , polymer , political science , law
The hypothesis that an electrostatic effect of the buried aspartate side chain may contribute considerably to the extreme catalytic power of serine proteinases is presented. This statement is based on an analysis of environmental effects, due to amino acid residues in the vicinity of the Ser‐221…His‐64 couple and to hydration in subtilisin BPN'.