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Binding of leucomycin and its derivatives to E. Coli ribosomes
Author(s) -
Jain D. V. S.,
Gombar Vijay
Publication year - 1981
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560200214
Subject(s) - ribosome , chemistry , acylation , stereochemistry , moiety , escherichia coli , ring (chemistry) , biochemistry , organic chemistry , rna , catalysis , gene
Structure‐activity relationships have been discussed for inhibition of [ 14 C] erythromycin binding to Escherichia coli ribosomes by leucomycin and its acyl derivatives in the light of the Fujita‐Ban de novo model. The group contributions of various substituents show that acylation at position 4″ of the mycarose moiety of leucomycin increases affinity for binding of leucomycins to ribosomes. It is also indicated that unlike at position 2' in mycaminose region a free hydroxyl at position 9 of the lactone ring is not important for binding to ribosomes.