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Electron transfer reactions in endoplasmic reticulum: Free radical production, lipid peroxidation, covalent binding and cell division
Author(s) -
Slater Trevor F.,
Ahmed Mustaq,
Benedetto Chiara,
Cheeseman Kevin,
Packer John E.,
Willson Robin L.,
Dianzani Mario U.
Publication year - 2009
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560180733
Subject(s) - endoplasmic reticulum , chemistry , lipid peroxidation , biophysics , reactive oxygen species , carbon tetrachloride , electron transfer , free radical theory of aging , radiolysis , membrane , biochemistry , photochemistry , covalent bond , radical , organic chemistry , enzyme , biology
The activation of carbon tetrachloride to a free radical product (CCl 3 ) by the NADPH‐cytochrome P 450 enzyme complex is used as an example to discuss aspects of electron flow in liver endoplasmic reticulum. The CCl 3 free radical may bind covalently to neighboring molecules, or may react rapidly with molecular oxygen to yield the highly reactive CCI 3 O 2 species. The kineties of reaction of this radical with various substances have been measured using pulse radiolysis techniques. The production of such a reactive radical in the lipid membrane may result in lipid peroxidation. This is a degradative reaction associated with the formation of a number of pharmacologically active materials. Lipid peroxidation is often much reduced in endoplasmic reticulum from cancer cells, and electron transfer reactions in such membranes can be severely disturbed. Some ideas leading to further experimentation in these areas are presented.