Premium
Relationship between spatial structure and pharmacological activity of a series of β‐adrenomimetics
Author(s) -
Zhorov B. S.,
Govyrin V. A.
Publication year - 1979
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560160310
Subject(s) - diastereomer , alkyl , substituent , chemistry , series (stratigraphy) , stereochemistry , organic chemistry , paleontology , biology
Abstract All equilibrium conformations of a series of N ‐alkyl‐α‐alkyl derivatives of noradrenaline and their synthetic precursors—phenylaminoketones—have been calculated. It has been shown that spasmodic changes in bronchodilating activity of the catecholamines, observed with the increase in α‐alkyl substituent size, may arise from the difference in the ratio of diastereoisomers produced by reduction of aminoketones.