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Possible connection between lipophilicity and steric substituent constants
Author(s) -
Tichy̌ Miloň
Publication year - 1979
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560160309
Subject(s) - steric effects , lipophilicity , substituent , chemistry , polar , connection (principal bundle) , computational chemistry , stereochemistry , mathematics , physics , quantum mechanics , geometry
Abstract The steric constants E s and ν have the greatest chance of being independent of lipophilic substituent constants. There is a high probability among hydrocarbon substituents that the steric constants correlate with the lipophilic ones, while in the case of polar substituents the probability is low.