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Mechanism of protein folding
Author(s) -
Ptitsyn O. B.,
Finkelstein A. V.
Publication year - 1979
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560160302
Subject(s) - protein folding , folding (dsp implementation) , chain (unit) , helix (gastropod) , polypeptide chain , chemistry , lattice protein , protein secondary structure , protein structure , electromagnetic coil , chemical physics , mechanism (biology) , crystallography , physics , biology , amino acid , biochemistry , ecology , quantum mechanics , astronomy , snail , electrical engineering , engineering
The first stage of protein self‐organization—the formation of a fluctuating secondary structure in the unfolded protein chain—is considered. The stereochemical theory is presented enabling one to calculate helix‐coil and β‐structure‐coil equilibrium constants. It is shown that the most probable localization of fluctuating α‐ and β‐structure in the unfolded protein chain corresponds to the native localization of these structures. The formation of large α‐ and β‐structural blocks is observed, each of them including several native α‐helices or β‐strands.