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Purine‐purine base pairs and the origin of transversion‐type mutation
Author(s) -
Gardun̄to Ramon,
Rein Robert,
Egan John T.,
Coeckelenbergh Yves,
Macelroy Robert D.
Publication year - 2009
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560120721
Subject(s) - transversion , tautomer , purine , chemistry , base pair , mutation , stereochemistry , pairing , purine metabolism , genetics , dna , computational chemistry , biochemistry , biology , physics , gene , quantum mechanics , enzyme , superconductivity
Purine‐purine mispairs involving tautomerization have recently been suggested as the source of transversion‐type mutations. Alternative purine pairs involving only normal tautomeric forms are also possible. The energetics of these pairing schemes are evaluated, and their effectiveness as mutational intermediates is compared. Our results indicate that pairs involving normal tautomeric forms are more likely to play a role in the mutational mechanism. The comparison of the calculated probabilities with mutational data is discussed.