Premium
Singlet oxygen molecules and carcinogenic aromatic hydrocarbons
Author(s) -
Cusachs Louis Chopin,
Steele Richard H.
Publication year - 2009
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.560010620
Subject(s) - carcinogen , chemistry , singlet oxygen , singlet state , molecule , computational chemistry , quantum chemical , excited state , photochemistry , oxygen , chemical physics , organic chemistry , atomic physics , physics
Consideration of the possible role of singlet excited oxygen molecules in cell processes offers a promising clue to the point of divergence in the metabolism of carcinogenic and noncarcinogenic polynuclear aromatic hydrocarbons. This hypothesis is supported by quantum‐mechanical calculations providing insight into the correlation obtained by Pullman and Pullman between carcinogenic activity and the indices of activity for K and L regions. The method employed is sufficiently general to be used with other classes of chemical compounds, some of whose members show carcinogenic activity.