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Self‐catalytic mechanism of prebiotic reactions: From formamide to purine bases
Author(s) -
Slavova Sofia,
Enchev Venelin
Publication year - 2020
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.26362
Subject(s) - formamide , chemistry , formic acid , hypoxanthine , nucleobase , catalysis , purine , ammonia , hydrogen cyanide , decomposition , organic chemistry , combinatorial chemistry , biochemistry , dna , enzyme
Abstract Complete reaction pathway of prebiotic reactions for formation of the purine nucleobases adenine, hypoxanthine, guanine, isoguanine, 2,6‐diaminopurine, and xanthine from pure formamide are presented. All reactants (hydrogen cyanide, ammonia, water, formic acid, urea) and catalysts (formamide and formimidic acid) needed in the self‐catalyzed reactions are available from a starting compound, formamide. The required raw materials are obtained by partial decomposition of formamide.