Cover Image, Volume 115, Issue 9

This perspective, Xingyong Wang, Tianying Yan and Jing Ma (DOI: 10.1002/qua.24829 ) give a brief overview of recent developments of polarizable force fields (FFs) – a kind of specific FF method that includes polarization effect into conventional molecular mechanics (MM). The commonly adopted polarizable models, i.e., the fluctuating charge (FQ) model, Drude model, and the inducible dipole (ID) model are expatiated. Taking advantage of the recent development of computational techniques and fragment‐based low‐scaling quantum mechanics (QM) methods, QM‐based polarizable FFs appeared and particularly aroused great interest in biological systems. Current applications and limitations of several models are discussed. Opportunities and challenges for future development are also addressed.