Premium
Theoretical study on the mechanism of the reaction for alkene hydroaminations catalyzed by chiral aldehyde
Author(s) -
Zhao Jinfeng,
Sun Chuanzhi,
Sun Nan,
Meng Lin,
Chen Dezhan
Publication year - 2013
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.24483
Subject(s) - hydroamination , aldehyde , chemistry , alkene , enantioselective synthesis , catalytic cycle , catalysis , nucleophile , reaction mechanism , computational chemistry , combinatorial chemistry , stereochemistry , organic chemistry
Alkene hydroamination catalyzed by chiral aldehyde relying only on temporary intramolecularity is a new concept reaction. In this article, the reaction mechanism was investigated using density functional theory. The calculation results show that: (1) The reaction can be divided into two parts. The first part is a dehydration process involving a hemiaminal formation. The nitrone catalyst forms through rapid intermolecular nucleophilic addition of benzylhydroxylamine to chiral aldehyde precatalyst. The second part is a catalytic cycle, which involves an aminal formation—hydroamination—ring opening—product release process. (2) There are four enantioselective pathways related to the products of S and R configurations. Enantioselectivity is attributed to the different forming ways of a planar five‐membered ring. The preferred pathways for the S ‐configuration product ( S3 ) and R ‐configuration product ( R3 ) are confirmed. © 2013 Wiley Periodicals, Inc.