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Self‐organization effects in reactions of macromolecules
Author(s) -
Christophorov L. N.
Publication year - 2010
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.22246
Subject(s) - macromolecule , reaction coordinate , chemistry , character (mathematics) , chemical physics , quantum , substrate (aquarium) , computational chemistry , biophysics , physics , biology , quantum mechanics , biochemistry , ecology , geometry , mathematics
The ability of biomacromolecules to coordinate fast reaction events in their active centers with slow rearrangements of their structure is focused upon. Under real conditions of many sequential reaction turnovers of the macromolecule, the structural shifts caused by single turnovers can be of cumulative character. This, in turn, leads to drastic threshold‐like changes of the reaction cycle. In this way, the creative role of dynamical substrate‐conformation interactions in the formation of functional regimes of the macromolecule is consistently uncovered. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010