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Protein interaction property similarity analysis
Author(s) -
Wade R. C.,
Gabdoulline R. R.,
De Rienzo F.
Publication year - 2001
Publication title -
international journal of quantum chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 105
eISSN - 1097-461X
pISSN - 0020-7608
DOI - 10.1002/qua.1204
Subject(s) - similarity (geometry) , property (philosophy) , protein–protein interaction , chemistry , scale (ratio) , biological system , computational chemistry , computational biology , statistical physics , chemical physics , physics , computer science , artificial intelligence , biology , biochemistry , quantum mechanics , philosophy , epistemology , image (mathematics)
Abstract We describe how similarity indices may be applied to semiquantitatively compare the molecular interaction fields, such as electrostatic and hydrophobic potentials, of proteins. We then review ways in which this approach has been used to investigate protein interaction properties in diverse applications ranging from in‐depth comparison of pairs of proteins to large‐scale analysis of hundreds of modeled protein structures. © 2001 John Wiley & Sons, Inc. Int J Quant Chem 83: 122–127, 2001