Open AccessA pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism
Author(s) -
MacLean Margaret R.,
Pandya Divya,
Swietlik Emilia M.,
Denver Nina,
Mair Kirsty,
Morrell Nicholas W.,
Gräf Stefan
Publication year - 2022
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1002/pul2.12139
Subject(s) - medicine , association (psychology) , estrogen , genetic association , class (philosophy) , physiology , bioinformatics , genetics , single nucleotide polymorphism , genotype , gene , psychotherapist , biology , psychology , artificial intelligence , computer science
The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism.