A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism | Zendy

MacLean Margaret R. | Zendy; Pandya Divya | Zendy; Swietlik Emilia M. | Zendy; Denver Nina | Zendy; Mair Kirsty | Zendy; Morrell Nicholas W. | Zendy; Gräf Stefan | Zendy

Open Access

A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism

Author(s) -

MacLean Margaret R.,

Pandya Divya,

Swietlik Emilia M.,

Denver Nina,

Mair Kirsty,

Morrell Nicholas W.,

Gräf Stefan

Publication year - 2022

Publication title -

pulmonary circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.791

H-Index - 40

ISSN - 2045-8940

DOI - 10.1002/pul2.12139

Subject(s) - medicine , body mass index , estrogen , cohort , association (psychology) , physiology , endocrinology , epistemology , philosophy

The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body‐weight in mice and man may be associated with increased estrogen metabolism.

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