Open AccessHuman pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: Potential implications for SARS‐CoV‐2 infection
Author(s) -
Toe Quezia K.,
Issitt Theo,
Mahomed Abdul,
Almaghlougth Fatma,
Bahree Ishan,
Sturge Charles,
Hu Xueqi,
Panselinas Ioannis,
BurkeGaffney Anne,
Wort Stephen, Jc,
Quinlan Gregory John
Publication year - 2022
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1002/pul2.12068
Subject(s) - medicine , angiotensin converting enzyme 2 , hepcidin , downregulation and upregulation , coronavirus , covid-19 , immunology , endothelial dysfunction , endothelial stem cell , virology , disease , inflammation , gene , infectious disease (medical specialty) , biology , biochemistry , in vitro
Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin‐converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome coronavirus 2, in these cells. We report ACE2 expression and positive regulation by both interleuki‐6, hepcidin, and ferroportin knock‐down in pulmonary artery endothelial cells with potential implications for viral infection.