Open AccessSuppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
Author(s) -
Liu Bin,
Yi Dan,
Pan Jiakai,
Dai Jingbo,
Zhu Maggie M.,
Zhao YouYang,
Oh S. Paul,
Fallon Michael B.,
Dai Zhiyu
Publication year - 2022
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1002/pul2.12056
Subject(s) - medicine , bmpr2 , pulmonary hypertension , lung , bone morphogenetic protein , signal transduction , pathophysiology of hypertension , cardiology , blood pressure , microbiology and biotechnology , biology , gene , biochemistry , chemistry
BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.