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Association of clozapine metabolism and neutropenia
Author(s) -
Lam Y. W. Francis
Publication year - 2021
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30766
Subject(s) - clozapine , neutropenia , medicine , absolute neutrophil count , white blood cell , leukopenia , limiting , schizophrenia (object oriented programming) , blood count , pharmacology , chemotherapy , psychiatry , mechanical engineering , engineering
Clozapine is highly effective in patients with treatment‐resistant schizophrenia. However, the occurrence of neutropenia and agranulocytosis in 1% to 2% of treated patients has necessitated the requirement of frequent hematological monitoring, limiting the usefulness of clozapine for more patients. Most clinical guidelines recommend that clozapine be discontinued when the white blood cell count is less than 3,000/µl or the absolute neutrophil count (ANC) is less than 1,500/µl in treated individuals.