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No significant difference by genotype in study of topiramate for alcohol use disorder
Publication year - 2021
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30728
Subject(s) - topiramate , alcohol use disorder , genotype , snp , single nucleotide polymorphism , alcohol , medicine , polymorphism (computer science) , oncology , genetics , psychiatry , biology , gene , biochemistry , epilepsy
A new study that confirmed the effect of topiramate in reducing heavy‐drinking days in patients with alcohol use disorder (AUD) did not find a moderating effect of the rs2832407 genotype on study outcomes. The latter finding contradicted previous research suggesting an association between the single nucleotide polymorphism (SNP) and AUD treatment response.