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Oral contraceptives and clozapine
Author(s) -
Lam Y. W. Francis
Publication year - 2020
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30603
Subject(s) - clozapine , cyp2c19 , medicine , pharmacokinetics , drug , pharmacology , cyp3a4 , cyp1a2 , schizophrenia (object oriented programming) , estrogen , psychiatry , cytochrome p450 , metabolism
Although clozapine is highly effective in managing patients with treatment‐resistant schizophrenia, its pharmacokinetic profile can be altered by multiple patient‐specific factors, including drug‐drug interaction. The elimination of clozapine in humans is primarily mediated by several drug‐metabolizing enzymes, including CYP1A2, CYP2C19, and CYP3A4. Oral contraceptives containing estrogen have been shown to inhibit CYP1A2 and CYP2C19.