Clozapine reinitiation found effective in patients who had discontinued drug

Reinitiation of clozapine was found to be among the safest and most effective treatment options for patients with schizophrenia who had discontinued use of clozapine, according to a national registry study. The results contradicted researchers' hypothesis that former users of clozapine should avoid resuming use based on limited efficacy or lack of tolerability. Results were published online Jan. 8 in The British Journal of Psychiatry .