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Medication maintenance drops recurrence; effects of behavioral therapy less clear
Publication year - 2020
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30552
Subject(s) - antidepressant , medicine , depression (economics) , cognitive behavioral therapy , randomized controlled trial , psychiatry , major depressive disorder , maintenance therapy , antidepressant medication , cognition , anxiety , chemotherapy , economics , macroeconomics
Antidepressant medication maintenance led to lower rates of depression recurrence than antidepressant withdrawal in a randomized trial involving patients who had recovered from a depressive episode, regardless of whether patients' initial treatment consisted of antidepressant monotherapy or an antidepressant in combination with cognitive behavioral therapy (CBT). The study surprisingly found that the effects of CBT were not long‐lasting, with the results calling into question the long‐term impact of widely used combination treatment approaches. Results were published online Dec. 4, 2019, in JAMA Psychiatry .