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Drugs and QT interval prolongation in patients with PTSD
Author(s) -
Lam Y. W. Francis
Publication year - 2019
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30391
Subject(s) - prolongation , qt interval , medicine , interval (graph theory) , anesthesia , mathematics , combinatorics
The potential risk of drug‐induced prolongation of the electrocardiographic QT interval has been a clinical concern with some drug classes due to the increased risk of developing a rare but life‐threatening atypical ventricular tachycardia known as torsades de pointes. This has led to the withdrawal of several drugs from the U.S. market, as well as a Drug Safety Communication issued by the Food and Drug Administration for citalopram, which is commonly prescribed off‐label for management of anxiety in patients with post‐traumatic stress disorder (PTSD).