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Altered clozapine concentrations associated with e‐cigarettes
Author(s) -
Lam Y. W. Francis
Publication year - 2019
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30383
Subject(s) - clozapine , antipsychotic drug , affect (linguistics) , schizophrenia (object oriented programming) , antipsychotic , drug , medicine , nicotine , cigarette smoke , smoke , pharmacology , psychiatry , environmental health , psychology , chemistry , communication , organic chemistry
Cigarette smokers have increasingly substituted traditional combustible cigarettes with electronic cigarettes, with the latter perceived by most consumers to be less harmful. However, there can be unanticipated drug interactions mediated by modulation of cytochrome P‐450 enzyme activity when a consumer switches from traditional cigarettes. This is especially relevant to patients with schizophrenia who are treated with clozapine, as they tend to smoke more and their smoking can affect metabolism of the antipsychotic.