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Altered clozapine concentrations associated with electronic cigarettes
Author(s) -
Lam Y. W. Francis
Publication year - 2018
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30351
Subject(s) - clozapine , schizophrenia (object oriented programming) , medicine , antipsychotic drug , drug , antipsychotic , pharmacology , pharmacokinetics , cytochrome p450 , psychiatry , metabolism
The atypical antipsychotic clozapine has unique efficacy in patients with treatment‐resistant schizophrenia. However, its pharmacokinetic profile is highly variable and can be altered by changes in metabolic capacity as a result of cytochrome‐P450‐mediated drug‐drug interactions. In addition, smoking can increase the metabolic capacity of patients treated with clozapine, possibly resulting in lower clozapine concentrations. A recent report documented changes in clozapine concentration in a patient who was a smoker and who transitioned from traditional cigarettes to electronic cigarettes.