Altered clozapine concentrations associated with electronic cigarettes | Zendy

Lam Y. W. Francis | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Altered clozapine concentrations associated with electronic cigarettes

Author(s) -

Lam Y. W. Francis

Publication year - 2018

Publication title -

the brown university psychopharmacology update

Language(s) - English

Resource type - Journals

eISSN - 1556-7532

pISSN - 1068-5308

DOI - 10.1002/pu.30351

Subject(s) - clozapine , schizophrenia (object oriented programming) , medicine , antipsychotic drug , drug , antipsychotic , pharmacology , pharmacokinetics , cytochrome p450 , psychiatry , metabolism

The atypical antipsychotic clozapine has unique efficacy in patients with treatment‐resistant schizophrenia. However, its pharmacokinetic profile is highly variable and can be altered by changes in metabolic capacity as a result of cytochrome‐P450‐mediated drug‐drug interactions. In addition, smoking can increase the metabolic capacity of patients treated with clozapine, possibly resulting in lower clozapine concentrations. A recent report documented changes in clozapine concentration in a patient who was a smoker and who transitioned from traditional cigarettes to electronic cigarettes.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research