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Limited evidence of baclofen's effectiveness in alcohol disorder treatment
Publication year - 2018
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30337
Subject(s) - baclofen , abstinence , craving , placebo , anxiety , alcohol dependence , alcohol , medicine , agonist , alcohol use disorder , psychiatry , randomized controlled trial , anesthesia , psychology , clinical psychology , addiction , receptor , biology , biochemistry , alternative medicine , pathology
A meta‐analysis encompassing 12 randomized controlled trials comparing baclofen and placebo on a number of alcohol use outcomes found that abstinence rates were the only variable for which baclofen showed a significant advantage. The gamma‐aminobutyric acid B agonist showed no significant differences from placebo on measures of days abstinent, heavy drinking days, alcohol craving, depression, or anxiety, the researchers found.