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Comprehensive analysis of antidepressants finds modest differences in efficacy
Publication year - 2018
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30327
Subject(s) - placebo , medicine , depression (economics) , placebo response , drug , clinical trial , psychiatry , intensive care medicine , alternative medicine , pathology , economics , macroeconomics
A comprehensive analysis of placebo‐controlled and head‐to‐head trials of the available drug treatments for depression has found that all antidepressants were more efficacious than placebo. There were some modest differences among individual drugs in the degree to which they reduced depressive symptoms. Although the available data do not offer guidance on which patients will respond best to individual medications, this analysis is believed to provide the best available evidence to date to inform clinical practice. Results of the analysis were published online Feb. 21 in The Lancet .