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Hormone therapy effective in preventing depressive symptoms in menopause transition
Publication year - 2018
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30318
Subject(s) - menopause , transdermal , medicine , placebo , hormone therapy , depressive symptoms , hormone , randomized controlled trial , hormone replacement therapy (female to male) , climacteric , surgical menopause , postmenopausal women , estrogen , gynecology , psychiatry , alternative medicine , pharmacology , anxiety , testosterone (patch) , pathology , cancer , breast cancer
Transdermal estradiol plus intermittent micronized progesterone over 12 months was more effective than placebo in preventing the development of clinically significant depressive symptoms in perimenopausal and early postmenopausal women, a randomized trial has found. The benefits seen from hormonal therapy did not extend to women in later stages of the menopause transition, according to the researchers. Study results were published online Jan. 10 in JAMA Psychiatry .