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Rhabdomyolysis after risperidone
Author(s) -
Lam Y. W. Francis
Publication year - 2017
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30265
Subject(s) - rhabdomyolysis , medicine , homeostasis , creatine kinase , muscle fibre , calcium , myocyte , necrosis , endocrinology , skeletal muscle
Rhabdomyolysis is a potentially life‐threatening syndrome that reflects lysis of muscle fibers secondary to disruption of the calcium homeostasis in muscle cells. This results in leakage of toxic cellular contents into the systemic circulation, eventually leading to muscle destruction and fiber necrosis. Patients with the condition usually exhibit significantly elevated serum creatine kinase.