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D‐cycloserine shows small effect in augmenting CBT for anxiety disorders
Publication year - 2017
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30230
Subject(s) - cycloserine , placebo , anxiety , partial agonist , antidepressant , agonist , generalized anxiety disorder , medicine , psychology , pharmacology , clinical psychology , psychiatry , receptor , alternative medicine , tuberculosis , pathology
The partial N‐methyl‐D‐aspartate agonist D‐cycloserine resulted in greater improvement post‐treatment compared with placebo as augmentation of exposure‐based therapy in patients with an anxiety disorder, but the effect was small and the difference with placebo was not sustained at follow‐up, a meta‐analysis has found. Contrary to researchers' hypothesis prior to the review, antidepressant use did not moderate the effects of D‐cycloserine.