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Post‐hoc analysis in Alzheimer's study shows benefit of LMTM monotherapy
Publication year - 2017
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30212
Subject(s) - post hoc analysis , medicine , post hoc , disease , oncology , alzheimer's disease , pooled analysis , confidence interval
A randomized, double‐blind, parallel‐group study of a tau protein aggregation inhibitor, while not showing treatment benefit in the primary analysis of its effect on slowing disease progression in Alzheimer's disease patients, found significant results in a post‐hoc analysis for patients receiving the drug as monotherapy. Patients receiving leuco‐methylthioninium bis[hydromethanesulfonate] (LMTM) monotherapy at doses of either 75 or 125 mg twice a day saw benefits in both cognition and activities of daily living, researchers reported. Study results were published online Nov. 15, 2016, in The Lancet .